After a major Week 1 in college football, Week 2 also offers many intriguing games. A whopping 24 of the top 25 ranked teams are in action, including one monster matchup with two of them squaring off.
No. 16 Iowa State faces in-state rival Iowa at 12 p.m. ET on FOX, as the two in-state rivals look to continue undefeated campaigns. The Cyclones are 3.5-point favorites in that contest, and they aren’t the only ranked team facing a challenging unranked foe at noon ET. No. 17 SMU hosts Baylor, and No. 11 Illinois travels to Duke in that window as well, and both the Mustangs and Illini are only 2.5-point favorites.
At 3:30 p.m. ET, an SEC affair takes place with No. 20 Ole Miss (-8.5) playing its first road contest of the campaign against Kentucky. Several top-10 teams are also in action at 3:30 p.m. ET, including No. 1 Ohio State facing Grambling and No. 6 Oregon taking on Oklahoma State on CBS/Paramount+.
Then in prime time, No. 15 Michigan and No. 18 Oklahoma will battle in Norman at 7:30 p.m. on ABC. The Sooners are currently residing at -4.5, as each powerhouse looks to move to 2-0 on the young season. This is also a big stage for two potential Heisman contenders. Oklahoma signal-caller John Mateer is tied for the fourth-lowest Heisman odds (+1200) at Caesars Sportsbook, while true freshman Michigan quarterback Bryce Underwood is further down the board at +4000.
